Abirapro is belongs to type of anti-cancer medication that will act by decline the androgen production in the body. Androgen is a male hormone that can maintance the tumor cell in prostate glands, the main ingredient which is used as abiraterone. Actually this drug is given by co administration with prednisolone, a steroid which reduce the liability of side effects produced by abiraterone.
MECHANISM OF ACTION
Androgens are balance the production of malignant in prostate. Abirapro 250mg belongs to anti androgen drugs, Abirapro 250mg tablet that causes to suppress the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is involves in androgen conglomerate. Reduce the serum testosterone level. Declined the tumor cell occurred.
SAFETY AND WARNING OF ABIRAPRO
Anyallergy, serious liver problem or pregnant in patient, abiraterone should be stopped Avoid taking of other medications, i.e prescription, over-the-counter, vitamins, herbal remedies, etc be sure to inform the doctors before the treatment. Do not take Aspirin administrated and products containing aspirin till doctor particularly allow the drug.
PHARMACOKINETICS
Absorption:
- Time to maximum plasma concentration of Abirapro 250mg tablet takes 12 hours.
Distribution:
- Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.
Metabolism:
- Themain two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate.
Excretion:
- The drug mainly excreted in 88% feces and 5% in urine Half-life of tablet Abirapro 250mg is 12 ± 5 hours.
SIDE EFFECTS
Common effects Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency,Mineral corticoid deficiency, Hepatotoxicity, Hypertension, Decrease in ka level, Adrenocortical insufficiency Musculo skeletal and Connective tissue disorders:Joint swelling, discomfort, muscle discomfort General Disorder:Oedema Cardiac disorders:Hot flush, hypertension, arrhythmias, chest pain, cardiac failure GIT disorders:Diarrhea, dyspepsia Infections and Infestation:UTI Pulmonary disorder:Cough Renal:Urinary frequency, nocturia Injuries:Fractures
OVERDOSAGE
Abirapro 250mg has no essential antidote, If overdose of Abirapro 250mg occurs end treatment with the drug and give general supportive measures such as monitoring arrhythmias and cardiac failure and assess liver function.
CONTACT DETAILS
Phone : 9987711567
Email : applepharmaceutical@gmail.com
Email : info@myapplepharma.com
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