- Abiraterone is sold under brand name Abirapro 500mg.
- Abirapro 500mg is belongs to type of anti-cancer medication that will act by decline the androgen production in the body.
- Androgen is a male hormone that can maintained the tumor cell in prostate glands.
- This drug is given by co administration with prednisolone, a steroid which reduce the liability of side effects produced by Abiraterone.
DOSAGE
The prescribed dose of Abirapro is initial as 4 tablets given orally once daily.
The drug Abirapro administrated combination with 5mg prednisolone twice daily in empty stomach.
- Abirapro 500mg tablet given on an empty stomach.
- Food should not be taken for at least 2 hours before and at least 1 hour after the dose of Abirapro 500mg tablet is taken.
- Swallowed whole with water.
- Chew the tablets or Do not crush
MECHANISM OF ACTION
- Androgens are balance the production of malignant in prostate.
- Abirapro 500mg belongs to anti androgen drugs, that causes to suppress the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is involving in androgen conglomerate.
- Reduce the serum testosterone level.
- Declined the tumor cell occurred.
PHARMACOKINETICS
Absorption:
- Time to maximum plasma concentration of Abirapro 500mg tablet takes 12 hours.
Distribution:
- Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.
Metabolism:
- The main two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate.
Excretion:
- The drug mainly excreted in 88% feces and 5% in urine
- Half-life of tablet Abirapro 500mg is 12 ± 5 hours.
SAFETY AND WARNING
- Any allergy, serious liver problem or pregnant in patient, Abirapro 500mg therapy should be stopped Avoid taking of other medications, i.e. prescription, over-the-counter, vitamins, herbal remedies, etc. be sure to inform the doctors before the treatment.
- Do not take Aspirin administrated and products containing aspirin till doctor particularly allow the drug.
DRUG INTERACTION
- Interaction of Abirapro 500mg tablet with dextromethorphan will raises the Cmax and AUC of dextromethorphan Interaction Abirapro 500mg with strong CYP3A inhibitors or inducers, concomitant use with caution because pharmacokinetics is not evaluated.
STORAGE
- The drug stored at 15℃-30℃ Keep the drug in dry place.
MISSED DOSE
- If patient missed the dose of Abirapro 500mg, that missed dose will be skipped and follow the regular dosing schedule.
SIDE EFFECTS
- Common effects:Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency, Mineral corticoid deficiency, Hepatotoxicity, Hypertension, Decrease in ka level, Adrenocortical insufficiency Muscular skeletal and Connective tissue disorders: Joint swelling, discomfort, muscle discomfort
- General Disorder: Edema
- Cardiac disorders: Hot flush, hypertension, arrhythmias, chest pain, cardiac failure
- GIT disorders: Diarrhea, dyspepsia
- Infections and Infestation: UTI
- Pulmonary disorder: Cough
- Renal: Urinary frequency, nocturia
- Injuries: Fractures.
OVERDOSAGE
- Abirapro 500mg tablet has no essential antidote, If overdose occurs end treatment with the drug and give general supportive measures such as monitoring arrhythmias and cardiac failure and assess liver function.
CONTACT DETAILS
Phone : 9987711567
Email : applepharmaceutical@gmail.com
Email : info@myapplepharma.com
katherine 