- Tafero EM is an antiretroviral drug containing two eminent ingredients known as; Tenofovir alafenamide fumarate Emtricitabine Tenofovir alafenamide nucleotide translation inhibitor and a transcription inhibitor.
- Ambos son provides effective action against potential VIH-1 infections, without any additional conditions, alone to prevent HIV infection with VIH-1 and SIDA.
- In Tafero EM Tablet , TAF Form. Emtricitabine is a synthetic fluoride derivative of thiacytidine.
INDICATION
- Tafero EM , a combined tablet containing Tenofovir alafenamide fumarate in Emtricitabine is primarily indicated for the Treatment of HIV-1 infection in adult patients.
DOSAGE
This is a condition for oral treatment orally in oral form. Important points; Before starting treatment, the patient should examine to detect cases of hepatitis B infection no. The patient’s renal values should Research on the creation of creatinines, including in vivo. Tafero-MS should be determined in teenascents, pediatric patients weighing at least 25 kg and the creatinine clearance of the patients should be greater than 30 ml / min. Tafero-EM does not require special use, and in the first place – 30 ml / min. Tafero EM Tablet must be Administered with food or without food.
PHARMACOLOGY
- Tafero EM contains Tenofovir alafenamide fumarate and emtricitabine TAF null knot – pharmacologically simple inverted transcriptase inhibitors, including controversial by profession. It is changed as a functional structure in vivo, known as tenofovir.
- Tenofovir experimental materials on the construction of buildings and structures.
- El Atomo de Aguas es Basico-para-el-de-enlas-de-enlas-phosphodiester. Tenofovir is of great importance for all areas related to ADN and is an interference between 5 ‘a 3’ Member States and is important for the prolongation of ADN.
- Tenofovir Comprometido Con; Chain scrap DNA stretch end Stops the interpretation of Emtricitabine proviral DNA; Emtricitabine imagine orders de to deter el chemical viral Reverse transcriptase di es essential pair creation viral. Emtricitabine Inclie; Chain elimination Stops the increase in HIV RNA duplicates Serves to emulate viral load
What the body does to Tafero-EM after administration
- Отчеты об устном обращении: о поглощении Tafero EM should occur very quickly and the maximum plasma time of tenofovir is 1 hour. The average absolute bioavailability of emtricitabine is производит 93%. Food doses do not affect the abstention of Tafero-MS.
- The Natural Organization for the Protection of Human Rights, Tafero-EM is; TAF: 80%; Emtricitabine: 4% of tafero-EM metabolism; TAF is hydrolysed to an active form called Tenofovir by the use of cathepsin A or carboxylesterase 1.
- El metabolism de la Tenofovir alafenamide biotransformation mediad. El Período de Semivida Terminal de Tafero-EM es; TAF: 0.51 h. Emtricitabine: 10 h. As a result of the removal of tafero-EM, traumatic activation occurs and the filtering membrane of the kidney proceeds.
SAFETY MEASURES
- Hepatitis B gravity: Hepatitis B virus infection not.
- It has not evaluated the effectiveness of Tafero EM Tablet for Advanced Hepatitis B infection.
- This condition mainly occurred in patients infected with HIV-1 / HBV. Immune System Reconstitution Syndrome: The Problem of Super-Pretoria Intercommunity Relations with Tafero-EM.
- Renal failure: on-duty kidney Tafero-EM with medications that affect kidney functions. Monitoring the situation in the field of creativity and freedom. Under conditional conditions, CrCl and below 30 ml / min should be avoided . Tafero EM . Lactic acidosis and hepatic steatosis: discontinue therapy with Tafero-MS
DRUG INTERACTION
- Tafero EM + P-gp o BCRP inhibitory potentials: afectan la abscicin de TAF. Inductive potentials from P-gp o BCRP from Tafero-EM +: reduced TAF absorption in terms of reduction = final plasma concentration and the final result from determining the effectiveness of Tafero-EM.
- El Process de elimination de Tafero EM occurs traves – de – los – kidneys, l combination de Tafero – EM con medications Affecting la activity renal causes un increase del Effect de concentration de Ingredients de Tafer de de de de de de de de de de Tafero effects Adverse Associates Estos Components.
- Tafero EM Tablet combines with medications such as tipranavir / ritonavir and decreases the effect of концентрат TAF. Tafero-EM used simultaneously with anticonvulsants causes a decrease in the effect of концентрат TAF. Tafero-EM used simultaneously with anti-mycobacteria or St. John’s wort causes a decrease in the effect of концентрат TAF.
CONTRAINDICATION
- Tafero EM is contraindicated for patients with cyclic below 30 ml / min. This may be due to inconsistencies related to components such as Tafero-EM.
OVERDOSE
- Tafero EM overdose should be treated with hemodialysis.
- Sorry, but don’t forget that you have 30% of the vote. 3 hours work. THIS IS A TABLE OF DIPLICATES IN 54% OF DECADE REST FROM 4 DECADES.
PEDIATRIC
- Potential and effectiveness of Tafero EM Tablet not estimated at 25 kg.
GERIATRIC
- The no power of Tafero EM should not be evaluated in clinical trials couple geriatric patients scammers Age over 65 years.
RENAL DAMAGE
- Ce The OVO of Tafero EM Tablet should be avoided in cyclic patients Below 30 ml / min.
SIDE EFFECTS
- Lactic acidosis, hepatic steatosis, severe exacerbation of hepatitis B, regenerative immunity syndrome, new outbreak or aggravation of renal failure.
Some side effects are:
- Increased cholesterol levels, increased serum creatinine level, effects of density – CD + cells varies.
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